Essential histone chaperones collaborate to regulate transcription and chromatin integrity
نویسندگان
چکیده
منابع مشابه
Histone chaperones regulate histone exchange during transcription.
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. Th...
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Nucleosomes physically block access to the DNA, raising several questions (1) How are new nucleosomes formed in vivo? (2) How are nucleosomes removed to facilitate DNA templated processes? and (3) How are histones restored to the DNA following the completion of those processes? The intrinsic attraction between the negatively charged DNA phosphate backbone and the positively charged lysine and a...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2021
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.348431.121